The estimated minimum annual incidence of TGA is 3.4 per 100,000, though this is likely to be much higher as some people will not present to the hospital and others will be misdiagnosed.

Meta-analysis has found no predominance for either gender. Typically, it occurs in individuals aged 50–80 years, with decreased incidence in younger and older populations. Transient global amnesia (TGA) presents as sudden onset anterograde amnesia, with some features of retrograde amnesia, without residual cognitive impairment, of duration < 24 h. We have found that depression, previous head injury and family history of dementia may predict TGA recurrence. ConclusionsĭWI lesions were not significantly associated with outcomes (recurrence, subjective memory impairment, dementia). DWI lesions were observed in 24 patients and were located anywhere within the hippocampus. Of 15 patients with confirmed recurrent TGA, two developed dementia and four subjective memory impairment. recurrent, 15.4% vs 46.7%, p = 0.01) and family history of dementia (isolated vs. Risk factors associated with recurrence were head injury (isolated vs. Eighty-four patients had possible comorbidities or risk factors for TGA, though no single risk factor was ubiquitous. ResultsĪmong precipitating events, physical activities inducing Valsalva-like manoeuvres were most common, followed by emotional stress. Fifteen of 93 (16%) patients experienced a recurrence of TGA. Patients were followed from 2004 to 2016. We evaluated clinical history, family history and magnetic resonance diffusion-weighted imaging (DWI) studies of 93 prospective patients with TGA.

We attempted to determine risk factors for TGA, as well as prognostic factors that may cause recurrence. Aetiology of transient global amnesia (TGA) remains uncertain, though many have been proposed, including ischaemic, migrainous or epileptic pathologies.

Amnesia vs dementia